Cancer and Metabolism - Transformer by Nick Lane
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Analysis of Transformer by Nick Lane, exploring cancer metabolism, mutations, and the Warburg effect.
In Transformer: The Deep Chemistry of Life and Death, Nick Lane explores the complex role of metabolism in cancer development. On page 194, he discusses how different mutations are found in separate regions of the same tumor, indicating that no single mutation is responsible for starting the cancer. This suggests that cancer evolves over time through a variety of genetic changes rather than a single, traceable cause.
Lane references Otto Warburg's theory, which argues that cancer cells shift their energy production to favor glycolysis even in the presence of oxygen—a process known as the Warburg effect. This metabolic shift may be a driving factor behind cancer growth, not just a result of genetic mutations. The focus on altered metabolism challenges the view that cancer is purely a genetic disease, opening new possibilities for therapeutic approaches targeting cellular energy pathways.
Collections
Book - Recommends
Cancer Evolution
by Charles Swanton
Notes: Focuses on how cancer cells’ energy reprogramming supports growth.
Book - Refers
Transformer: The Deep Chemistry of Life and Death
by Nick Lane
Notes: Primary reference for this analysis on cancer metabolism.
Book - Recommends
Life Ascending
by Nick Lane
Notes: Provides context on the evolution of metabolism.
Book - Recommends
Cancer as a Metabolic Disease
by Thomas Seyfried
Notes: In-depth analysis of metabolic pathways altered in cancer.
Book - Recommends
Power, Sex, Suicide
by Nick Lane
Notes: Explores mitochondria’s role in energy, evolution, and cancer.
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